ZFIN ID: ZDB-GENE-030131-574
Gene Name: intraflagellar transport 88 homolog
Gene Symbol: ift88    Nomenclature History

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Previous Names: ovl, fb37b11, intraflagellar transport protein 88 (1), oval, polaris (1), ttc10 (1), wu:fb37b11, xx:zah8127

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have kinesin binding activity. Involved in several processes, including cilium organization; neuron development; and tissue homeostasis. Localizes to axoneme and ciliary basal body. Is expressed in forerunner cell group; head; nervous system; and pronephric duct. Orthologous to human IFT88 (intraflagellar transport 88).
Genome Resources: Alliance (1),  Gene:321855 (1),  Ensembl(GRCz11):ENSDARG00000027234 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ift88_unspecified Unspecified Unknown Unknown
sa7628 Point Mutation Unknown Missense ENU
sa8799 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18944 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27381 Point Mutation Unknown Premature Stop ENU
    sa41401 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tz288 Point Mutation Exon 11 Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ift88
    1
    CRISPR2-ift88
    1
    CRISPR3-ift88
    1
    MO1-ift88 N/A 11
    MO2-ift88 N/A 5
    MO3-ift88 N/A 7
    MO4-ift88 N/A 6
    MO5-ift88 N/A 1
    MO6-ift88 N/A 1
    MO7-ift88 N/A 1
    PHENOTYPE
    Data: 46 figures from 28 publications
    Observed in:
    DISEASE ASSOCIATED WITH ift88 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ift88 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component axoneme (more)
    Molecular Function kinesin binding (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ift88-201 (1)    Ensembl 2941
    ift88-203 (1)    Ensembl 602
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-ift88 Rabbit IHC 1
    Ab1-ift88 polyclonal Rabbit IHC, WB 13
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ift88 No data available
    MARKER RELATIONSHIPS
    ift88 Contained in: [BAC] DKEY-51D17 (1) (order this)
    ift88 Encodes: [EST] fb37b11, zah8127
    [cDNA] MGC:193654 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001725 (1) 2897 nt
    Genomic GenBank:CR392366 (1) 125898 nt
    Select Tool
    Polypeptide UniProtKB:F1QVN7 (1) 855 aa
    Sequence Information (all 43)
    ORTHOLOGY for ift88 ( Chr: 9 )
    CITATIONS (93)