Gene
ift88
- ID
- ZDB-GENE-030131-574
- Name
- intraflagellar transport 88 homolog
- Symbol
- ift88 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable kinesin binding activity. Acts upstream of or within with a positive effect on cilium assembly. Acts upstream of or within several processes, including cerebrospinal fluid circulation; photoreceptor cell maintenance; and plasma membrane bounded cell projection organization. Located in axoneme and ciliary basal body. Is expressed in forerunner cell group; head; nervous system; and pronephric duct. Orthologous to human IFT88 (intraflagellar transport 88).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 56 figures from 34 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ift88_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| sa7628 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa8799 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18944 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27381 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41401 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tz288 | Allele with one point mutation | Exon 11 | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ift88 | Thomas et al., 2014 | |
| CRISPR2-ift88 | Thomas et al., 2014 | |
| CRISPR3-ift88 | Chen et al., 2017 | |
| MO1-ift88 | N/A | (14) |
| MO2-ift88 | N/A | (6) |
| MO3-ift88 | N/A | (7) |
| MO4-ift88 | N/A | (8) |
| MO5-ift88 | N/A | Bisgrove et al., 2005 |
| MO6-ift88 | N/A | Bisgrove et al., 2005 |
| MO7-ift88 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|
|
UniProtKB:A0A8M9Q4H3
|
842 | ||
|
UniProtKB:A0A8M9QJI0
|
872 | ||
|
UniProtKB:A0A8M2BF03
|
841 | ||
|
UniProtKB:A0A8M9PRW8
|
856 | ||
|
UniProtKB:A0A8M2BEW9
|
826 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51D17 | ZFIN Curated Data | |
| Encodes | EST | fb37b11 | ||
| Encodes | EST | zah8127 | ||
| Encodes | cDNA | MGC:193654 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001725 (1) | 2897 nt | ||
| Genomic | GenBank:CR392366 (1) | 125898 nt | ||
| Polypeptide | UniProtKB:A0A8M9QJI0 (1) | 872 aa |
- Boldizar, H., Friedman, A., Stanley, T., Padilla, M., Galdieri, J., Sclar, A., Stawicki, T.M. (2024) The role of cilia in the development, survival, and regeneration of hair cells. Biology Open. 13(9):
- Xie, H., Kang, Y., Liu, J., Huang, M., Dai, Z., Shi, J., Wang, S., Li, L., Li, Y., Zheng, P., Sun, Y., Han, Q., Zhang, J., Zhu, Z., Xu, L., Yelick, P.C., Cao, M., Zhao, C. (2023) Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. PLoS Biology. 21:e3002008e3002008
- Wang, J., Thomas, H.R., Thompson, R.G., Waldrep, S.C., Fogerty, J., Song, P., Li, Z., Ma, Y., Santra, P., Hoover, J.D., Yeo, N.C., Drummond, I.A., Yoder, B.K., Amack, J.D., Perkins, B., Parant, J.M. (2022) Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants. Disease models & mechanisms. 15(12):
- Xie, H., Wang, X., Jin, M., Li, L., Zhu, J., Kang, Y., Chen, Z., Sun, Y., Zha, C. (2022) Cilia regulate meiotic recombination in zebrafish. Journal of molecular cell biology. 14(7)
- Aparicio, G., Rodao, M., Badano, J.L., Zolessi, F.R. (2021) Photoreceptor progenitor dynamics in the zebrafish embryo retina and its modulation by primary cilia and N-cadherin. The International journal of developmental biology. 65:439-455
- Cardenas-Rodriguez, M., Austin-Tse, C., Bergboer, J.G.M., Molinari, E., Sugano, Y., Bachmann-Gagescu, R., Sayer, J.A., Drummond, I.A. (2021) Genetic compensation for cilia defects in cep290/NPHP6 mutants by upregulation of cilia-associated small GTPases. Journal of Cell Science. 134(14):
- Cheung, K.Y., Jesuthasan, S.J., Baxendale, S., van Hateren, N.J., Marzo, M., Hill, C.J., Whitfield, T.T. (2021) Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection. Frontiers in Physiology. 12:626080
- Fang, X., Peden, A.A., van Eeden, F.J.M., Malicki, J.J. (2021) Identification of additional outer segment targeting signals in zebrafish rod opsin. Journal of Cell Science. 134(6):
- Geng, F., Ma, J., Li, X., Hu, Z., Zhang, R. (2021) Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration. International Journal of Molecular Sciences. 22(8):
- Leventea, E., Zhu, Z., Fang, X., Nikolaeva, Y., Markham, E., Hirst, R.A., van Eeden, F.J.M., Malicki, J.J. (2021) Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor. Proceedings of the National Academy of Sciences of the United States of America. 118(28):
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