Gene

unc45b

ID
ZDB-GENE-020919-3
Name
unc-45 myosin chaperone B
Symbol
unc45b Nomenclature History
Previous Names
  • unc45r (1)
  • cb393 (1)
  • fb37f02
  • wu:fa05a03 (1)
  • wu:fa10f03
  • wu:fb37f02
  • wu:fb96f06
  • wu:fc10f04 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have Hsp90 protein binding activity. Involved in lens development in camera-type eye; striated muscle cell development; and striated muscle tissue development. Localizes to Z disc. Is expressed in several structures, including cardiovascular system; eye; mesoderm; musculature system; and myoblast. Human ortholog(s) of this gene implicated in cataract 43. Orthologous to human UNC45B (unc-45 myosin chaperone B).
Genome Resources
Note
None
Expression
All Expression Data
29 figures from 15 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
24 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With unc45b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 43 Alliance ?Cataract 43 616279
Associated With unc45b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013026 Tetratricopeptide repeat-containing domain
Domain IPR024660 UNC-45/Cro1/She4, central domain
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Repeat IPR000225 Armadillo
Repeat IPR019734 Tetratricopeptide repeat
Domain Details Per Protein
Protein Length Armadillo Armadillo-like helical Armadillo-type fold Tetratricopeptide-like helical domain superfamily Tetratricopeptide repeat Tetratricopeptide repeat-containing domain UNC-45/Cro1/She4, central domain
UniProtKB:Q6DGE9 934
UniProtKB:E9QD76 79
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-unc45b polyclonal Rabbit
  • IHC
1
Ab2-unc45b polyclonal Guinea pig
  • IHC
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations