ZFIN ID: ZDB-GENE-001212-1
Gene Name: ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 1
Gene Symbol: atp1a1a.1    Nomenclature History

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Previous Names: atp1a1, atp[a]1B1 (1), cb70 (1), had (1), hip (1), hiphop (1), snk (1), heart and mind (1), snakehead (1), wu:fa03c03, wu:fb92h10 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits sodium:potassium-exchanging ATPase activity. Involved in several processes, including animal organ development; embryonic body morphogenesis; and regulation of heart rate. Predicted to localize to integral component of membrane. Is expressed in several structures, including cardiovascular system; immature eye; mesoderm; nervous system; and pronephros. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1).
Genome Resources: Alliance (1),  Gene:64612 (1),  Ensembl(GRCz11):ENSDARG00000002791 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3475Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la1 Indel Splice Junction Splice Site SPONTANEOUS
    la028094Tg Transgenic Insertion Unknown Unknown DNA
    m115 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m273 Unknown Unknown Unknown ENU
    m291 Unknown Unknown Unknown
    m523 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m883 Point Mutation Exon 11 Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • mw15b Indel Exon 17 - Intron 17 Splice Junction Splice Site ENU
    s646 Unknown Unknown Unknown ENU
    sa12184 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13646 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15598 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19398 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31185 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38236 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tj223 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tl30 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm52 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • to273a Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tu236 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw3b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tx218 Point Mutation Exon 17 Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zko58a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko58b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-atp1a1a.1
    2
    MO1-atp1a1a.1 N/A 3
    MO2-atp1a1a.1 N/A 5
    MO3-atp1a1a.1 N/A 1
    MO4-atp1a1a.1 N/A 1
    MO5-atp1a1a.1 N/A 1
    DISEASE ASSOCIATED WITH atp1a1a.1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 2DD Alliance Charcot-Marie-Tooth disease, axonal, type 2DD 618036
    Hypomagnesemia, seizures, and mental retardation 2 618314
    DISEASE ASSOCIATED WITH atp1a1a.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process otolith development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function sodium:potassium-exchanging ATPase activity (more)
    GO Terms (all 32)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atp1a1a.1-201 (1)    Ensembl 3506
    ncRNA atp1a1a.1-002 (1) 867
    atp1a1a.1-003 (1)    Ensembl 416
    atp1a1a.1-004 (1)    Ensembl 313
    atp1a1a.1-005 (1)    Ensembl 652
    atp1a1a.1-006 (1)    Ensembl 772
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab3-atp1a1 polyclonal Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp1a1a.1 No data available
    MARKER RELATIONSHIPS
    atp1a1a.1 Contained in: [BAC] DKEY-208K14 (1) (order this)
    atp1a1a.1 Encodes: [EST] cb70 (1) (order this), fa03c03 (1), fb81h09 (1) (order this), fb92h10 (1)
    [cDNA] MGC:55250 (1), MGC:77580 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131686 (1) 3497 nt
    Genomic GenBank:CU185242 (1) 180192 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZU25 (1) 1028 aa
    Sequence Information (all 25)
    ORTHOLOGY for atp1a1a.1 ( Chr: 1 )
    CITATIONS (80)