FIGURE

Fig. 2

ID

ZDB-FIG-260924-35

Publication

Torres-Perez et al., 2026 - Disrupting fzd9b in Zebrafish Recapitulates Stress- and Anxiety-Like Behaviours Relevant to Williams Syndrome

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Disrupting fzd9b leads to delayed habituation to acoustic startle and altered expression of HPI-axis-related genes. A) Proportion of responders across all acoustic stimuli in 5 dpf larvae: for fzd9b^+/+ (N = 45), fzd9b^+/- (N = 91), and fzd9b^−/− (N = 43); data show mean ± SEM. B) Relative expression (log₁₀ scale) of HPI axis genes (mr, gr and crhb) measured by qPCR in pooled 5 dpf larvae (N = 5–3 per genotype, 16 larvae per pool); graphs show individual values and mean ± SEM. C) Social preferences correlation index (r) in juvenile zebrafish (20–22 dpf) for all contrasts tested (0 vs. 0, vs. 0 vs. 1 or vs. 0 vs. 3) in fzd9b^+/+ (dark grey), fzd9b^+/- (light grey) or fzd9b^−/− (white); each point represents an individual; bars show mean ± SEM. In all cases: ** p < 0.01, *** p < 0.001, **** p < 0.000 vs. corresponding pairwise comparison

Expression Data

Genes:	crhb nr3c1 nr3c2
Fish:	TU fzd9b^qm6/qm6 (TU) fzd9b^qm6/+ (TU)
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fzd9b^qm6/qm6 (TU) fzd9b^qm6/+ (TU)
Condition:	vibration, visible light
Observed In:	habituation social behavior whole organism
Stage Range:	Day 5 to Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Neurobiol.