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Torres-Perez et al., 2026 - Disrupting fzd9b in Zebrafish Recapitulates Stress- and Anxiety-Like Behaviours Relevant to Williams Syndrome

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Fig. 2 Disrupting fzd9b leads to delayed habituation to acoustic startle and altered expression of HPI-axis-related genes. A) Proportion of responders across all acoustic stimuli in 5 dpf larvae: for fzd9b^+/+ (N = 45), fzd9b^+/- (N = 91), and fzd9b^−/− (N = 43); data show mean ± SEM. B) Relative expression (log₁₀ scale) of HPI axis genes (mr, gr and crhb) measured by qPCR in pooled 5 dpf larvae (N = 5–3 per genotype, 16 larvae per pool); graphs show individual values and mean ± SEM. C) Social preferences correlation index (r) in juvenile zebrafish (20–22 dpf) for all contrasts tested (0 vs. 0, vs. 0 vs. 1 or vs. 0 vs. 3) in fzd9b^+/+ (dark grey), fzd9b^+/- (light grey) or fzd9b^−/− (white); each point represents an individual; bars show mean ± SEM. In all cases: ** p < 0.01, *** p < 0.001, **** p < 0.000 vs. corresponding pairwise comparison

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Neurobiol.