Gene

nr3c2

ID

ZDB-GENE-060531-23

Name

nuclear receptor subfamily 3, group C, member 2

Symbol

nr3c2 Nomenclature History

Previous Names

mineralocorticoid receptor (1)
MR (1)
mr (1)
si:ch211-189l17.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Exhibits steroid hormone receptor activity. Involved in multicellular organismal response to stress. Predicted to localize to nucleus. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Is expressed in several structures, including blood; eye; heart; liver; and pleuroperitoneal region. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

24 figures from 14 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

dq017617 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nr3c2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant pseudohypoaldosteronism type 1	Alliance	Pseudohypoaldosteronism type I, autosomal dominant	177735
		Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy	605115

Associated With nr3c2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
autism spectrum disorder	nr3c2^ct867/ct867 (AB/TL)	standard conditions	Ruzzo et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Domain	IPR001628	Zinc finger, nuclear hormone receptor-type
Family	IPR001723	Nuclear hormone receptor
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily

Domain Details Per Protein

Protein	Length	Nuclear hormone receptor	Nuclear hormone receptor, ligand-binding domain	Nuclear hormone receptor-like domain superfamily	Zinc finger, NHR/GATA-type	Zinc finger, nuclear hormone receptor-type
UniProtKB:A6YIH7 InterPro	970

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nr3c2-201 (1) Ensembl	Havana	2096 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	nr3c2-202 (1) Ensembl	Havana	1444 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations