FIGURE

Fig. 3

ID

ZDB-FIG-260731-25

Publication

Li et al., 2026 - The accumulation of methylglyoxal and acrolein impairs arginine homeostasis causing hyperglycemia and renal abnormalities in male zebrafish

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Fig. 3

Downregulated insulin signaling pathway in GLO1/AKR1A1A DKO zebrafish compared to WT.
A GSVA of RNA-sequencing data revealed the significantly downregulated pathways in pairwise comparisons (DKO vs WT, DKO vs AKR1A1AKO, DKO vs GLO1KO) at 96hpf. n = 5/6 biological replicates per group. The red frame represents insulin signaling and its downstream pathway. GSVA enrichment scores were compared between groups using a two-sided empirical Bayes moderated t-test implemented in the limma package. Plotted values represent -log10 of the unadjusted two-sided P values. GSVA, Gene Set Variation Analysis; hpf, hours of post fertilization. B Heat map of relative mRNA expression in the insulin signaling pathway gene set. Orange indicates higher expression and blue indicates lower expression. C Heat map of relative mRNA expression in MAPK signaling pathway gene set. Orange indicates higher expression and blue indicates lower expression.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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