FIGURE

Fig. 1

ID

ZDB-FIG-260731-23

Publication

Li et al., 2026 - The accumulation of methylglyoxal and acrolein impairs arginine homeostasis causing hyperglycemia and renal abnormalities in male zebrafish

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Fig. 1

GLO1/AKR1A1A DKO larvae exhibited increased MG and ACR levels simultaneously.
A MG levels were increased in GLO1/AKR1A1A DKO larvae compared to WT and AKR1A1AKO larvae. n = 4/5 biological replicates per group. Exact p values for each comparation are: WT vs. GLO1KO, p = 0.048; WT vs. DKO, p = 0.006; AKR1A1AKO vs. GLO1KO, p = 0.0108; AKR1A1AKO vs. DKO, p = 0.0012. MG, methylglyoxal. B ACR levels were increased in GLO1/AKR1A1A DKO compared to WT and GLO1KO larvae. n = 3/4 biological replicates per group. Exact p values for each comparation are: WT vs. AKR1A1AKO, p = 0.0491; WT vs. DKO, p = 0.0027; GLO1KO vs. DKO, p = 0.0181. ACR, acrolein. C–E 4-HNE, MDA and acetaldehyde concentrations were unchanged in DKO larvae compared to WT, GLO1KO and AKR1A1AKO larvae. n = 4/5 biological replicates per group. 4-HNE, 4-hydroxynonenal; MDA, malondialdehyde. F,G Glyoxal and 3-DG levels were unchanged in DKO larvae compared to WT, GLO1KO and AKR1A1AKO larvae. n = 6 biological replicates per group. 3-DG, 3-deoxyglocosone. The bars indicate mean ± SD values. Statistical analysis was performed by one-way ANOVA. ns, not significant, *p < 0.05, **p < 0.01. Source data are provided as a Source Data file.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	akr1a1a^{zf3750/zf3750} glo1^{zf3029/zf3029} glo1^{zf3029/zf3029}; akr1a1a^{zf3750/zf3750}
Observed In:	whole organism 3-deoxyglucosone whole organism 4-hydroxynonenal whole organism acetaldehyde whole organism acrolein whole organism glyoxal whole organism malonaldehyde whole organism methylglyoxal
Stage:	Day 4

Phenotype Detail

Acknowledgments

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