FIGURE

Fig. 4.

ID

ZDB-FIG-260522-49

Publication

Dockery et al., 2026 - Genes for 5'mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration

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Fig. 4.

The canonical eif4eb compensates from growth deficits in Δeif4e1c. (A) Adult (3-4mpf) Δeif4eb/Δeif4e1c double mutants are not underrepresented any more than Δeif4e1c single mutants. (B) The Δeif4eb/Δeif4e1c double mutants weigh (light blue) 40% less than the Δeif4e1c singles (light green) and 57% less than their wildtype (black) siblings (mean = 0.215 g, 0.159 g, 0.092 g, ANOVA p-value <0.0001, N = 107, 58, 91). (C) The double mutants are also shorter (mean = 26.6 mm, 24.6 mm, 20.0 mm, ANOVA p-value = 0.0024). (D, E) Δeif4eb/Δeif4e1c double mutant hearts have 34% the number of CMs versus wildtype siblings and 66% the number of CMs as the age-matched Δeif4e1c control group (mean = 2461, 1740, 1151, ANOVA p-value <0.0001, N = 15, 11, 12). Since eif4eb and eif4e1c are on the same chromosome individual mutants aren't recovered. Error bars represent mean ± s.e.m. Scale bar = 100um. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Expression Data

Antibody:	Ab5-mef2
Fish:	eif4e1c^pd370/pd370; eif4eb^os83/os83 eif4e1c^pd370/pd370; eif4eb^os84/os84
Anatomical Term:	heart
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eif4e1c^pd370/pd370 eif4e1c^pd370/pd370; eif4eb^os83/os83 eif4e1c^pd370/pd370; eif4eb^os84/os84
Observed In:	cardiac muscle cell heart whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 534, Dockery, R., Zevallos, M., McNulty, C., Zecchino, T., Ratermann, R., White, R., Kolonay, D., Baskin, K., Goldman, J.A., Genes for 5'mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration, 50-60, Copyright (2026) with permission from Elsevier. Full text @ Dev. Biol.