FIGURE

Figure 7

ID

ZDB-FIG-260413-140

Publication

Chen et al., 2026 - Machine learning and free energy clustering reveal PAH protein binding linked to AD risk

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Figure 7

Free energy landscape (FEL) of PARP1 binding with four PAHs

(A–D) Shown in order: benzo[a]pyrene, phenanthrene, fluoranthene, and pyrene. RMSD (root-mean-square deviation) measures the stability of a structure during simulation. Gyrate computes the radius of gyration of a molecule and the radii of gyration about the x, y, and z axes. GYRATE calculates the radius of gyration (Rg) of the group of atoms, including all effects due to atoms passing through periodic boundaries. A stable folded protein maintains a steady Rg value.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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