FIGURE

Scheme 1

ID

ZDB-FIG-260408-68

Publication

Zhang et al., 2026 - OGT mediates O-GlcNAcylation of MEIS2 and affects palatal osteogenic development

Other Figures

All Figure Page

Back to All Figure Page

Scheme 1

Schematic model depicting the regulation of palatal osteogenesis by OGT-mediated MEIS2 O-GlcNAcylation. In embryonic palatal mesenchymal stem cells, OGT catalyzes the O-GlcNAcylation of MEIS2 at Ser237. This modification stabilizes MEIS2 by inhibiting ubiquitin-proteasome-mediated degradation. Stabilized MEIS2 binds to the SHOX2 promoter to activate transcription, thereby promoting osteogenic differentiation and ensuring normal palatal fusion

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int J Oral Sci