FIGURE

Fig. 6

ID

ZDB-FIG-260408-62

Publication

Zhang et al., 2026 - OGT mediates O-GlcNAcylation of MEIS2 and affects palatal osteogenic development

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Fig. 6

O-GlcNAcylation of MEIS2 mediated by OGT on Ser237. a Co-IP confirmed the interaction between OGT and MEIS2 in HEPM cells. b Representative immunofluorescence staining was performed to determine subcellular OGT (green) and MEIS2 (red) localization in HEPM cells. Scale bar: 5 μm. c, d Exogenous MEIS2 in HEK293 cells and endogenesis MEIS2 in HEPM cells were observed by sWGA pull-down assays. Before harvesting, cells received 12 h treatment with 30 μΜ TMG or OSMI-1. e Cross-species protein sequence alignment of MEIS2. f sWGA pull-down assays were carried out in HEK293 cells. Plasmids encoding HA-MEIS2 (WT or S237A) transfected cells. g IB analyses of WCL and IP extracted from HA-WT or HA-S237A mutant-transfected HEK293 cells. Data were indicated by mean ± SD. n = 3 biologically independent experiments. P-values were computed by two-tailed t-tests, *P < 0.05, **P < 0.01

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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