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Scheme 1
Schematic model depicting the regulation of palatal osteogenesis by OGT-mediated MEIS2 O-GlcNAcylation. In embryonic palatal mesenchymal stem cells, OGT catalyzes the O-GlcNAcylation of MEIS2 at Ser237. This modification stabilizes MEIS2 by inhibiting ubiquitin-proteasome-mediated degradation. Stabilized MEIS2 binds to the SHOX2 promoter to activate transcription, thereby promoting osteogenic differentiation and ensuring normal palatal fusion
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Full text @ Int J Oral Sci