FIGURE

Fig. 4

ID

ZDB-FIG-260408-4

Publication

Hernandez Herrera et al., 2026 - ercc6 deficient zebrafish exhibit UV and metronidazole sensitivity, increased oxygen consumption, and impaired hair cell mechanoelectrical transduction which can be restored by the superoxide dismutase mimetic MnTBAP

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Fig. 4

Metronidazole sensitivity in ercc6−/− larvae. (A) Graph showing percent lethality of zebrafish embryos after 24-h exposure to 10 mM metronidazole. (B) Representative images of 5-days post fertilization zebrafish (24 h after treatment). The treated ercc6−/− embryos all died, with death being indicated by cessation of motility and visible heartbeat. Data is from 3 replicate experiments, with 15 fish per group, per experiment and is represented by mean ± SD. Each datapoint represents percent survival from 15 larvae. Differences between groups were evaluated via two-way ANOVA with multiple comparisons (****P-value<0.0001). Scale bar: 500 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT ercc6^{mn3001/mn3001}
Condition:	chemical treatment by environment: metronidazole
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.