FIGURE

Fig. 3.

ID

ZDB-FIG-260401-42

Publication

Karchner et al., 2026 - Using fish models to understand the role of aryl hydrocarbon receptor (AHR)-interacting protein (AIP) in controlling sensitivity and resistance to dioxin-like compounds in vivo

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Fig. 3.

Survival of AIP mutant fish. A) Killifish. Heterozygous aip^wh71 killifish were crossed and dead or moribund embryos and larvae were sampled and genotyped as described in Materials and Methods. At the end of 2 mo, all surviving larvae were fin-clipped and genotyped. The graph shows combined results from 2 independent clutches, totaling 162 larvae (56 wild-type, 67 heterozygous, 32 homozygous). B, C) Zebrafish. Heterozygous aip^wh86 (B) and aip^wh239 (C) zebrafish were crossed and dead or moribund embryos and larvae were sampled and genotyped as described in Materials and Methods. After 14 dpf, all survival larvae were genotyped. The graph shows representative results from 4 or 5 clutches (Table S2). Abbreviations: WT: Wild-type, HET: Heterozygous, HMZ: Homozygous, dpf: Days postfertilization.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aip^wh86/wh86 (TL) aip^wh239/wh239 (TL) aip^wh86/+ (TL) aip^wh239/+ (TL)
Observed In:	whole organism
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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