FIGURE

Figure 8.

ID

ZDB-FIG-260105-110

Publication

Michno et al., 2025 - Pneumolysin-dependent and independent non-canonical autophagy processes mediate host defense against pneumococcal infection

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Figure 8.

Involvement of ROS-independent LAP-like CASM of S. pneumoniae-containing vesicles. (A) Representative confocal images of control, tecpr1a cyba double knockdown or atg16l1 tecpr1a cyba triple knockdown CMV:GFP-Lc3 larvae infected systemically with approximately 1600 CFU of Ply-positive (D39 Δcps) and Ply-negative (D39 Δcps Δply) mKate2-labeled S. pneumoniae at 2 hpi. (B) Quantification of Lc3 associations with intracellular PLY-positive or PLY-negative S. pneumoniae within infected phagocytes of control, tecpr1a cyba double knockdown or atg16l1 tecpr1a cyba triple knockdown CMV:GFP-Lc3 larvae. Data are shown as mean ± standard deviation (SD). Data obtained from two independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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