FIGURE

Figure 6.

ID

ZDB-FIG-251130-29

Publication

Ren et al., 2025 - RPGRORF15 Mutations Disrupt Lysosomal Lipid Metabolism in Retinal Pigment Epithelium Cells and Cause Retinitis Pigmentosa

Other Figures

All Figure Page

Back to All Figure Page

Figure 6.

The deficiency of RPGR^ORF15 leads to lysosome dysfunction in RPE-1 cells. (A,B) Protein levels and quantification of phagocytosis related-genes in NC and siRPGR^ORF15 RPE-1 cells (n = 3 biological replicates). (C) Immunostaining of early endosomes (Rab5a), Rab7a, LAMP1, and CTSB in NC and siRPGR^ORF15 RPE-1 cells. Scale bar = 10 µm. (D,E) Lysotracker staining and quantification of signal dots per cell in NC and siRPGR^ORF15 RPE-1 cells (n = 28). Scale bar = 10 µm. Data are presented as mean ± SD. Statistical significance is indicated as not significant (ns), *P < 0.05, **P < 0.01, ***P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.