FIGURE

Figure 5.

ID

ZDB-FIG-251130-28

Publication

Ren et al., 2025 - RPGRORF15 Mutations Disrupt Lysosomal Lipid Metabolism in Retinal Pigment Epithelium Cells and Cause Retinitis Pigmentosa

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Figure 5.

The deficiency of rpgra results in impaired lysosome in zebrafish retina. (A) Immunostaining analysis and quantification (B) for LAMP1 on retinal cryosection of 1.5 and 2 mpf zebrafish. Signals are indicated by white arrows (n = 7). Scale bar = 30 µm. (C) Immunofluorescence staining and quantification (D) for Lysotracker on RPE flat-mounted eyecups of 1.5 and 2 mpf zebrafish. Signals are represented by white arrows (n = 25). Scale bar = 10 µm. Data are presented as mean ± SD. Statistical significance is indicated as not significant (ns), *P < 0.05, **P < 0.01, ***P < 0.001.

Expression Data

Antibody:	Ab8-lamp1
Fish:	WT rpgra^{zf4007/zf4007}
Anatomical Term:	retinal pigmented epithelium lysosome
Stage:	Days 45-89

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rpgra^{zf4007/zf4007}
Observed In:	retinal pigmented epithelium lysosome retinal pigmented epithelium lysosome organization retinal pigmented epithelium regulation of lysosomal lumen pH
Stage:	Days 45-89

Phenotype Detail

Acknowledgments

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