FIGURE

Figure 4

ID

ZDB-FIG-251031-212

Publication

Zeng et al., 2025 - The Zebrafish miR-183 Family Regulates Endoderm Convergence and Heart Development via S1Pr2 Signaling Pathway

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Figure 4

miR-96/182 overexpression leads to cardia bifida. (A–C) 48 hpf Tg (cmlc2: eGFP) transgenic zebrafish embryo cardiac fluorescence image (ventral view). (A) Control embryos show a normally fused heart tube (green). Embryos of miR-96 OE (B) and miR-182 OE (C) exhibit cardia bifida phenotypes (white arrow heads indicate two separated cardiac primordia). (D,E) Quantification of cardia bifida in miR-96 OE and miR-182 OE embryos. (F–I) WISH detected the expressions of cmlc2 (F,F’,F”), vmhc (G,G’,G”), gata4 (H,H’,H”), and nppa (I,I’,I”) in the control, miR-96 OE, and miR-182 OE embryos at 48 hpf (red arrow heads indicate two separated cardiac primordia). The numbers in the lower right corner indicate the number of embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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