FIGURE

Fig. 4

ID

ZDB-FIG-251008-4

Publication

Han et al., 2025 - The repurposed STAT3 inhibitor pyrimethamine controls mycobacterial infection-induced vascular permeability and mycobacterial burden

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Fig. 4

Direct antibiotic effect of pyrimethamine against M. marinum and M. tuberculosis, but not M. abscessus, cultures in vitro. (A) Growth curve of M. marinum treated with atovaquone as indicated. (B) Growth curve of M. marinum treated with pyrimethamine as indicated. (C) Minimum inhibitory concentration determination of M. tuberculosis treated with pyrimethamine at concentrates indicated in μM. (D) Growth curve of M. abscessus treated with pyrimethamine as indicated. (E) Growth curve of M. marinum treated with 6.25 μM pyrimethamine (PYR) and 100 μM tetrahydrofolic acid (THF). Statistical comparisons are of technical replicates of Day 7 OD600 readings by ANOVA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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