FIGURE

Fig. 1

ID

ZDB-FIG-251008-1

Publication

Han et al., 2025 - The repurposed STAT3 inhibitor pyrimethamine controls mycobacterial infection-induced vascular permeability and mycobacterial burden

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Fig. 1

Genetic depletion of STAT3 reduces infection-induced vascular permeability. (A) Quantification of stat3 transcripts in 8 day post fertilization zebrafish embryos. (B) Microangiography of 6 dpi M. marinum-infected zebrafish embryos allows quantification of vascular permeability by fluorescent microscopy. Red boxes indicate areas of infection-induced vascular leak. Blue boxes indicate areas of dorsal aorta ventral to granulomas used for normalization. (C) Quantification of M. marinum burden in 6 dpi trunk infected stat3 crispant zebrafish embryos. (D) Quantification of infection-induced vascular permeability in 6 dpi trunk infected stat3 crispant zebrafish embryos. (E) Quantification of M. marinum burden in 6 dpi trunk infected stat3 mutant zebrafish embryos. (F) Quantification of infection-induced vascular permeability in 6 dpi trunk infected stat3 mutant zebrafish embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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