FIGURE

Fig. 3

ID

ZDB-FIG-251008-3

Publication

Han et al., 2025 - The repurposed STAT3 inhibitor pyrimethamine controls mycobacterial infection-induced vascular permeability and mycobacterial burden

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Fig. 3

Atovaquone and pyrimethamine do not interact with isoniazid, and pyrimethamine treatment inhibits M. marinum growth in zebrafish embryos. (A) Quantification of M. marinum burden in trunk infected zebrafish embryos treated with 50 µM atovaquone or pyrimethamine and 200 µM isoniazid (INH) from 5 to 7 dpi by immersion and infused with isoniazid (INH) at 5 dpi. (B) Quantification of M. marinum burden in trunk infected zebrafish embryos treated with 50 µM atovaquone or pyrimethamine from 5 to 7 dpi by immersion and infused with isoniazid (INH) at 5 dpi. (C) Representative images of 5 dpi M. marinum-infected zebrafish embryos treated with 25 µM pyrimethamine from 0 to 5 dpi. (D) Quantification of M. marinum burden in systemically infected embryos treated with 25 µM pyrimethamine from 0 to 5 dpi. (E) Quantification of infection engraftment in embryos infection with a limiting dose of M. marinum and pretreated with 25 µM pyrimethamine for one day prior to infection. Statistical test by two-sided Fisher’s Exact Test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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