FIGURE

Fig. 14

ID

ZDB-FIG-250807-71

Publication

Misra et al., 2025 - Tirzepatide mitigates cognitive decline in zebrafish model of type 2 diabetes mellitus induced by high-fat diet

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Fig. 14

Effect of TZP on protein expression of GSK-3β and total AMPK level in zebrafish in old and young age group, A GSK-3β; B AMPK activity. After the treatment of TZP, the level of AMPK was considerably increased in both age groups as compared to HFD group and GSK-3β was reduced in TZP-treated groups. The statistical data analysis is presented by two-way ANOVA analysis by employing the Bonferroni post-test. Values presented as mean ± SD (p < 0.05), a vs. control, TZP (10 nM) per se, a vs. HFD, b vs. HFD + TZP (10 nM), c vs. HFD + DPZ (5 mg/kg). Values presented as mean ± SD (p < 0.05), α vs. HFD (young age group), β vs. HFD + TZP (young age group) (n = 3). A [F (4, 20) = 8.86, p = 0.0003], B [F (4, 20) = 1.63, p = 0.2065]

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Naunyn-Schmiedeberg's Arch. Pharmacol.