FIGURE

FIGURE 6

ID

ZDB-FIG-250805-37

Publication

Bai et al., 2025 - Effects of realgar-indigo naturalis formula on a zebrafish tumor xenograft model induced by human acute promyelocytic leukemia cells: antitumor activity, hepatotoxicity, and transcriptomic analysis

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 6

Mechanism of the combination therapy in synergistically suppressing APL through triple-axis targeting of the proteasome, ferroptosis, and lysosome pathways. (A) GO analysis reveals marked perturbations in ubiquitin-proteasome system (UPS) processes, including ubiquitin-dependent/independent proteolysis, proteasome assembly, and enhanced proteasomal degradation regulation, alongside disrupted iron ion homeostasis and autophagosome dynamics. (B) KEGG pathway enrichment indicates significant activation of the proteasome pathway (central to proteostasis), ferroptosis, glutathione metabolism (linked to oxidative stress), and concurrent enrichment of neurodegenerative disease pathways (e.g., Parkinson’s and Alzheimer’s). (C,D) GSEA validates robust modulation of the proteasome and lysosome pathways.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol