FIGURE

Fig. 5

ID

ZDB-FIG-250730-85

Publication

Ingham et al., 2025 - Loss of SLX4IP leads to Common Fragile Sites instability and compromises DNA interstrand crosslink repair in vivo

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Fig. 5

SLX4IP functions with SLX4 to maintain chromosome stability but also display SLX4-independent functions. A, Representative pictures of SLX4IP-, SLX4-and co-depleted U2OS cells. B, G1 53BP1 N.Bs in cells treated with indicated siRNA (mean ± SD; n = 3 biological replicates; >2000 cells analyzed per condition). C, proliferation of cells treated with indicated siRNA. Co-depleted conditions are pooled (mean ± SD; n = 2 biological replicates). D, S-phase EdU intensity and (E) representative EdU profiles from indicated transfections (mean; n = 2 biological replicates; 10′000 cells per condition are shown). Significance was assessed by Student's unpaired t-tests. Scale bar: 10 μM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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