FIGURE

Fig. 3

ID

ZDB-FIG-250730-83

Publication

Ingham et al., 2025 - Loss of SLX4IP leads to Common Fragile Sites instability and compromises DNA interstrand crosslink repair in vivo

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Fig. 3

SLX4IP-deficient U2OS cells exhibit global chromosomal instability markers. A, G1 53BP1 N.Bs in siCtrl- and siSLX4IP-transfected U2OS cells (mean ± SD; n = 3 biological replicates; >2000 cells analyzed per condition). Cyclin A-positive cell marked by an asterisk for reference. B, micronuclei (MN) in siCtrl- and siSLX4IP-transfected U2OS cells (mean ± SD; n = 3 biological replicates; >1000 cells analyzed per condition). C, G1 53BP1 N.Bs in U2OS SLX4IP KO cells and EV cells (mean ± SD; n = 3 biological replicates; >1500 cells analyzed per condition). Significance was assessed by Student’s unpaired t-tests. Scale bars: 10 μM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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