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ID: ZDB-IMAGE-250730-77
Publication: Ingham et al., 2025 - Loss of SLX4IP leads to Common Fragile Sites instability and compromises DNA interstrand crosslink repair in vivo
All Figures: Figures for Ingham et al., 2025

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Fig. 3 SLX4IP-deficient U2OS cells exhibit global chromosomal instability markers. A, G1 53BP1 N.Bs in siCtrl- and siSLX4IP-transfected U2OS cells (mean ± SD; n = 3 biological replicates; >2000 cells analyzed per condition). Cyclin A-positive cell marked by an asterisk for reference. B, micronuclei (MN) in siCtrl- and siSLX4IP-transfected U2OS cells (mean ± SD; n = 3 biological replicates; >1000 cells analyzed per condition). C, G1 53BP1 N.Bs in U2OS SLX4IP KO cells and EV cells (mean ± SD; n = 3 biological replicates; >1500 cells analyzed per condition). Significance was assessed by Student’s unpaired t-tests. Scale bars: 10 μM.

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