FIGURE

Figure 8

ID

ZDB-FIG-250615-18

Publication

Lin et al., 2025 - Phage-Antibiotic Synergy Enhances Biofilm Eradication and Survival in a Zebrafish Model of Pseudomonas aeruginosa Infection

Other Figures

All Figure Page

Back to All Figure Page

Figure 8

Phage–antibiotic combination therapy outperforms phage therapy alone in zebrafish rescue. (A) Evaluation of toxic responses and determination of the semi-lethal dose (LD₅₀) in zebrafish over 24 h following cloacal injections of three different P. aeruginosa bacterial loads. The results show that an injection of 10⁷ CFU results in the semi-lethal dose being reached within 24 h. (B) Survival rates of zebrafish treated with a combination of phiLCL12 and 1/2 MIC imipenem for 3 days assessed using 10⁷ CFU dose as the semi-lethal threshold. “+” indicates the presence of the indicated treatment or component; “–“ indicates its absence. “***” indicates p < 0.001, “**” indicates p < 0.01, “*” indicates p < 0.05. “ns” indicates not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.