ZFIN Image: Lin et al., 2025, Figure 8

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Figure Caption

Figure 8

Phage–antibiotic combination therapy outperforms phage therapy alone in zebrafish rescue. (A) Evaluation of toxic responses and determination of the semi-lethal dose (LD₅₀) in zebrafish over 24 h following cloacal injections of three different P. aeruginosa bacterial loads. The results show that an injection of 10⁷ CFU results in the semi-lethal dose being reached within 24 h. (B) Survival rates of zebrafish treated with a combination of phiLCL12 and 1/2 MIC imipenem for 3 days assessed using 10⁷ CFU dose as the semi-lethal threshold. “+” indicates the presence of the indicated treatment or component; “–“ indicates its absence. “***” indicates p < 0.001, “**” indicates p < 0.01, “*” indicates p < 0.05. “ns” indicates not significant.

Acknowledgments

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