FIGURE

Fig. 7

ID
ZDB-FIG-250423-79
Publication
Wu et al., 2025 - KDM4C works in concert with GATA1 to regulate heme metabolism in head and neck squamous cell carcinoma
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Fig. 7

Schematic illustration of KDM4C-GATA1 axis in heme metabolism and cancer progression. In the active state (top panel), KDM4C interacts with GATA1, demethylating H3K9me3 marks at heme metabolism gene promoters such as FECH, opening chromatin, and promoting gene transcription. This upregulation supports cancer cell growth and migration. Upon KDM4C inhibition (bottom panel), H3K9me3 demethylation is blocked, leading to a repressive chromatin state, downregulating heme metabolism genes, and reducing cancer growth and migration

Expression Data

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Phenotype Data

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