FIGURE

Figure 5

ID

ZDB-FIG-250417-138

Publication

Minoia et al., 2025 - Antioxidant, Osteogenic, and Neuroprotective Effects of Homotaurine in Aging and Parkinson's Disease Models

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Figure 5

Evaluation of homotaurine’s effects on LRRK2-G2019S mutated midbrain organoids size and ROS levels during differentiation in 8 pooled organoids for each condition. (A) Representative images of mock-treated (top) and homotaurine-treated (bottom) NESC colonies, whose diameters are indicated. (B) The area (size, µm²) of LRRK2-G2019S-mutated midbrain organoids derived from mutated iPSC lines was assessed at multiple differentiation time points (6, 9, 28, and 40 days). Homotaurine treatment did not alter colony size compared to untreated (UNTR) controls, indicating that homotaurine does not adversely affect colony growth during differentiation. (C) Cytofluorimetric analysis revealed a significant reduction in ROS levels in homotaurine-treated samples at day 40 of differentiation. (* p < 0.05).

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)