FIGURE

Figure 4

ID

ZDB-FIG-250417-137

Publication

Minoia et al., 2025 - Antioxidant, Osteogenic, and Neuroprotective Effects of Homotaurine in Aging and Parkinson's Disease Models

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Figure 4

Expression of neuronal markers in 3D neuronal epithelial stem cell (NESC) organoids derived from induced pluripotent stem cells (iPSCs) carrying the leucine-rich repeat kinase 2 (LRRK2) G2019S mutation. (A) Three-dimensional NESC organoids generated from both gene-corrected (GC) and (B) mutated (MUT T413) iPSC lines were stained with antibodies against TH, GFAP, and MAP2 neuronal markers and visualized using confocal microscopy. Representative micrographs are shown. (C) Through a semi-quantitative analysis of the images, we observed reductions in the expression levels of all examined neuronal markers: tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), and microtubule-associated protein 2 (MAP2) in the NESC 3D colonies derived from the LRRK2-G2019S-mutated T413 cell line, compared to the gene-corrected GC counterpart. In blue nuclei, in purple the MAP2 marker, in red the TH marker and in green the GFAP marker (* p < 0.05).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)