FIGURE

Figure 6

ID

ZDB-FIG-250417-139

Publication

Minoia et al., 2025 - Antioxidant, Osteogenic, and Neuroprotective Effects of Homotaurine in Aging and Parkinson's Disease Models

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Figure 6

Modulation of Wnt signaling effectors by homotaurine treatment of LRRK2-G2019S-mutated midbrain organoids. (A) Gene expression analysis for 4 pooled organoids revealed an increase in CTNNB1 gene expression levels in response to homotaurine treatment. (B) Protein analysis for 4 pooled organoids showed an increase in total β-catenin and RUNX2, along with a decrease in the phosphorylated form of β-catenin, indicating the activation of the Wnt signaling pathway. (* p < 0.05; ** p < 0.01; *** p < 0.005). In the Western blot images, the lanes in the middle marked with the ‘X’ do not contain samples from this study. The original Western blot images are provided in Supplementary Materials S3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)