ZFIN Image: Minoia et al., 2025, Figure 5

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Figure Caption

Figure 5

Evaluation of homotaurine’s effects on LRRK2-G2019S mutated midbrain organoids size and ROS levels during differentiation in 8 pooled organoids for each condition. (A) Representative images of mock-treated (top) and homotaurine-treated (bottom) NESC colonies, whose diameters are indicated. (B) The area (size, µm²) of LRRK2-G2019S-mutated midbrain organoids derived from mutated iPSC lines was assessed at multiple differentiation time points (6, 9, 28, and 40 days). Homotaurine treatment did not alter colony size compared to untreated (UNTR) controls, indicating that homotaurine does not adversely affect colony growth during differentiation. (C) Cytofluorimetric analysis revealed a significant reduction in ROS levels in homotaurine-treated samples at day 40 of differentiation. (* p < 0.05).

Acknowledgments

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