FIGURE

Fig. 6

ID

ZDB-FIG-250402-29

Publication

Li et al., 2025 - Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis

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Fig. 6

Alteration of hyaloid vasculature in larvae treated with MG-H1, which could be rescued by MG-H1 scavenger. (A) Scheme of experimental design for hyaloid vasculature exploration in larvae treated with MG-H1 with or without CAR rescue. Figure was created with BioRender.com. (B) Representative confocal images of the hyaloid vasculature showed amplified alterations in WT, GLO1KO and ALDH3A1KO larvae treated with 1 mM MG-H1, and attenuated alterations in larvae co-treated with 1 mM MG-H1 and 10 mM CAR. White scale bar = 20 μm. (C) Increased hyaloid branch points in WT, GLO1KO and ALDH3A1KO larvae treated with 1 mM MG-H1 was observed compared to the larvae without treatment, but no alteration was observed in DKO larvae treated with MG-H1, and these vasculature alterations can be rescued by CAR. n = 12–14. The bars indicate mean ± SD values. Statistical analysis was applied by one-way ANOVA, ns = not significant, **p < 0.01, ***p < 0.001. hpf, hours of post fertilization; dpf, days of post fertilization; w/o, with or without; MG-H1, methylglyoxal-derived hydroimidazolone 1; CAR, L-Carnosine.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Metab. Clin. Exp.