FIGURE

Fig. 3

ID

ZDB-FIG-250402-26

Publication

Li et al., 2025 - Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis

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Fig. 3

Differential gene expression analysis and GSVA. (A) DGE analysis between each two group (DKO vs GLO1KO, DKO vs ALDH3A1KO, DKO vs WT, GLO1KO vs WT, ALDH3A1KO vs WT). (B) GSVA of RNA-sequences showed the significantly downregulated pathways between each two group (DKO vs WT, ALDH3A1KO vs WT, GLO1KO vs WT, DKO vs ALDH3A1KO, DKO vs GLO1KO) at 96hpf. n = 5 clutches with 20 larvae in each group. (C) GSVA of RNA-sequences showed the significantly upregulated pathways between each two group (DKO vs WT, ALDH3A1KO vs WT, GLO1KO vs WT, DKO vs ALDH3A1KO, DKO vs GLO1KO) at 96hpf. n = 5 clutches with 20 larvae in each group. DGE, differential gene expression; GSVA, gene set variation analysis; hpf, hours of post fertilization.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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