Fig. 7
- ID
- ZDB-FIG-250324-42
- Publication
- Kobar et al., 2024 - tp53 R217H and R242H mutant zebrafish exhibit dysfunctional p53 hallmarks and recapitulate Li-Fraumeni syndrome phenotypes
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DNA methylation changes in tp53 mutant zebrafish affects cell signalling, metabolic processes, and biological macromolecule synthesis and degradation. A) Primary component analysis (PCA) plot shows clustering of the bulk WGBS wildtype, tp53 null, R217H/R217H and R242H/R242H pooled 5 dpf zebrafish samples. B) Dichotomous diagram of the WGBS samples using the Ward clustering method with a correlation distance method. C) Heatmap showing the percent methylation of 150 DMRs identified from 1000 bp windows with an FDR < 0.05 and a methylation differences of >25 %. D) Dot plots showing the top ten GO BP (D) and KEGG pathway (E) terms, ranked by combined score, between each genotype comparison. Enrichment analysis was performed on 226 genes that were associated with the 150 DMRs. Dot size corresponds to the ratio of associated genes per total number of genes for each term and the colour corresponds to the combined score. |
Reprinted from Biochimica et biophysica acta. Molecular basis of disease, 1871, Kobar, K., Tuzi, L., Fiene, J.A., Burnley, E., Galpin, K.J.C., Midgen, C., Laverty, B., Subasri, V., Wen, T.T., Hirst, M., Moksa, M., Carles, A., Cao, Q., Shlien, A., Malkin, D., Prykhozhij, S.V., Berman, J.N., tp53 R217H and R242H mutant zebrafish exhibit dysfunctional p53 hallmarks and recapitulate Li-Fraumeni syndrome phenotypes, 167612167612, Copyright (2024) with permission from Elsevier. Full text @ BBA Molecular Basis of Disease