FIGURE

Fig 8

ID

ZDB-FIG-250321-16

Publication

Nonarath et al., 2025 - The USH3A causative gene clarin1 functions in Müller glia to maintain retinal photoreceptors

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Fig 8

Interactions between Müller glia and cone photoreceptor cells are disorganized in clrn1^-/-zebrafish.

En face images from Tg(gfap:GFP); Tg(gnat2:Lifeact-mCherry) 7 dpf transgenic zebrafish at the level of UV cone outer segments in either (a-d) wild-type or (e-h) clrn1^-/- retina. Comparison of higher magnification images of (d) wild-type versus (h) clrn1^-/- highlight abnormal interactions between Müller glia apical processes and cone calyceal processes within mutants. (i-n) En face images from Tg(gfap:GFP); Tg(gnat2:Lifeact-mCherry) 7 dpf transgenic zebrafish at the level of the OLM just apical of the adherens junctions, Müller glia processes encircle photoreceptors. Comparison of (i) wild-type versus (l) clrn1^-/- highlight disorganization in mutants. At this image plane, actin is not well detected in (j) wild-types, but accumulates in (m) clrn1^-/- cone photoreceptors. (o) Cartoon showing the imaged planes. Scale bar (c) = 5 µm. Schematic in (o) created in BioRender under License: https://BioRender.com/x12n534.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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