Figure 1

High-glucose treatment resulted in the generation of a zebrafish model of type 2 diabetes mellitus (T2DM). (a) Intraperitoneal glucose tolerance test (IPGTT) curve for zebrafish after 4 weeks of high-glucose treatment (0.5 mg/g body weight (BW)); (b) area under the glucose tolerance curve after 4 weeks of high-glucose treatment; (c) insulin content in skeletal muscle after 4 weeks of high-glucose treatment; (d) IPGTT curve for zebrafish after 8 weeks of high-glucose treatment; (e) area under the glucose tolerance curve after 8 weeks of high-glucose treatment; and (f) insulin content in skeletal muscle after 8 weeks of high-glucose treatment. (g) Total cholesterol (T-CHO); (h) triglyceride (TG); (i) high-density lipoprotein-cholesterol (HDL-C); and (j) low-density lipoprotein-cholesterol (LDL-C). (k) IPGTT curve for zebrafish after normal breeding for 8 weeks following high-glucose intervention for 8 weeks; (l) area under the glucose tolerance curve for zebrafish after normal breeding for 8 weeks following high-glucose intervention for 8 weeks; and (m) insulin content in skeletal muscle of zebrafish after normal breeding for 8 weeks following high-glucose intervention for 8 weeks. * p < 0.05, ** p < 0.01, *** p < 0.001. (n = 6 samples/group).