FIGURE

Figure 1

ID

ZDB-FIG-241219-74

Publication

Marcone et al., 2024 - Targeting Radiation Resistance in Oesophageal Adenocarcinoma with Pyrazinib-Functionalised Gold Nanoparticles

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Figure 1

Pyrazinib-functionalised gold nanoparticles (AuNP-P3) enhanced radiosensitivity in an the OAC cell line model of radioresistance. The effect of pyrazinib-coupled gold nanoparticles (AuNP-P3), pyrazinib (P3), and gold nanoparticles (AuNPs) at 10 µM treatment on the radiosensitivity of OE33P (radiation sensitive) and OE33R (radioresistant) cells was assessed by clonogenic assays and compared to the control (0.1% DMSO + 0.1% water). Surviving fraction of OE33P (A) and OE33R (B) cells following treatment with compounds at 10 µM and 2 Gy X-ray radiation. Clonogenic assay was used to assess cell survival based on the ability of a single cell to grow into a colony after receiving treatment with the compound at 10 µM. Cell viability was assessed in mock-radiated OE33P (C) and OE33R cells (D). Data are expressed as mean ± SEM. Statistical analysis was carried out using a two-tailed paired t-test. * p < 0.05, ** p < 0.01, *** p < 0.001 (n = 4).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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