FIGURE

Fig. 3

ID

ZDB-FIG-241217-30

Publication

Dernovšek et al., 2024 - Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders

Other Figures

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Fig. 3

Schematic representation of the structural modifications that were designed based on the predicted binding mode of 11 in the N-terminal ATP-binding site of Hsp90β. In the SAR exploration study, the substituents at positions 1, 2 and 4 of the core phenyl ring will be modified in order to determine the most favorable combination to increase affinity for Hsp90β and selectivity against Hsp90α.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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