FIGURE

Fig. 6

ID

ZDB-FIG-241217-33

Publication

Dernovšek et al., 2024 - Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders

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Fig. 6

. Induction of apoptosis (A) and cell cycle arrest (B) in MCF-7 cells by compound 24e. MCF-7 cells were exposed to 15 μM or 75 μM 24e. After 24 h or 48 h, apoptosis was measured by annexin V-PE/Sytox Blue staining, and cell cycle progression was assessed by propidium iodide. A) Percentages of viable (non-apoptotic), early apoptotic and late apoptotic cells – left, and representative scatter plots of annexin V-PE (x-axis) and Sytox blue (y-axis) – right. B) Representative cell cycle graphs and percentages of cells in each phase of the cell cycle. Data are presented as the means ± SD of at least two biological replicates. ∗p < 0.05, ∗∗p < 0.01 (Person's t-test): treatment vs. control at time point.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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