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Fig. 3 Schematic representation of the structural modifications that were designed based on the predicted binding mode of 11 in the N-terminal ATP-binding site of Hsp90β. In the SAR exploration study, the substituents at positions 1, 2 and 4 of the core phenyl ring will be modified in order to determine the most favorable combination to increase affinity for Hsp90β and selectivity against Hsp90α.
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Full text @ Eur. J. Med. Chem.