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Fig. 6

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ZDB-FIG-241209-50

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Lange et al., 2024 - A multimodal zebrafish developmental atlas reveals the state-transition dynamics of late-vertebrate pluripotent axial progenitors

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Fig. 6

Zebrahub confirms the existence of early LPM progenitors contributing to pronephron and endothelial cells (A) Reprojection (UMAP) of the lateral plate mesoderm cells and its progeny from Figure 3A UMAP (10–24 hpf). Right: new annotated UMAP and the corresponding velocity. (B) Distribution of the cell time proportion over time. (C) UMAP color coded by time. (D) UMAP plots showing the expression of endothelial/hematopoietic progenitors etv2, tal1, lmo2, the endothelial marker npas4l, the pronephron markers sox17 and pax2a, the erythroid marker hbae3, and the mesothelium marker hand2. (E) In silico photoconversion of the early LPM territory. Left: selected territory at the initial time point. Top right: localization of the cells at the last time points. Bottom right: zoom in on the dashed rectangle (see also Data S1). (F) Transverse schematic section of the zebrafish embryo at 20 hpf. On the UMAPs, the blue arrows indicate the localization of the early progenitors, while the yellow arrows indicate the late progenitors. In the microscopy projection and the transverse section, orange arrows indicate the ISV (intersomitic vessels), while red arrows indicate the pronephron duct.

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Acknowledgments

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Reprinted from Cell, 187(23), Lange, M., Granados, A., VijayKumar, S., Bragantini, J., Ancheta, S., Kim, Y.J., Santhosh, S., Borja, M., Kobayashi, H., McGeever, E., Solak, A.C., Yang, B., Zhao, X., Liu, Y., Detweiler, A.M., Paul, S., Theodoro, I., Mekonen, H., Charlton, C., Lao, T., Banks, R., Xiao, S., Jacobo, A., Balla, K., Awayan, K., D'Souza, S., Haase, R., Dizeux, A., Pourquie, O., Gómez-Sjöberg, R., Huber, G., Serra, M., Neff, N., Pisco, A.O., Royer, L.A., A multimodal zebrafish developmental atlas reveals the state-transition dynamics of late-vertebrate pluripotent axial progenitors, 6742-6759.e17, Copyright (2024) with permission from Elsevier. Full text @ Cell