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Fig. 1

ID

ZDB-FIG-241119-88

Publication

Yin et al., 2024 - Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts

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Fig. 1

Metastatic conjunctival melanoma cells induce angiogenesis and recruitment of macrophages in a zebrafish angiogenesis model. a Schematic representation of the angiogenesis assay in zebrafish xenografts. Cancer cells or 2% PVP used as vehicle are injected into the PVS at 2 day post fertilization (dpf) zebrafish larvae Tg(kdrl:EGFP^s843; mpeg1:GAL4-VP16^gl24; UAS-E1b: NfsB-mCherryⁱ¹⁴⁹). In response to a strong angiogenic signal, the SIV complex is deformed towards the injection focus. b Representative images of time-lapses recording the angiogenic response to the SIV from 2 to 24 hpi. c Quantifications of the angiogenic activity induced by engraftment of CoM cells at 24hpi as measured by the angle, total length, and elongation of the SIV complex

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