FIGURE

Fig. 2

ID

ZDB-FIG-241119-89

Publication

Yin et al., 2024 - Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts

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Fig. 2

Chemical ablation of macrophages inhibits tumor-induced angiogenesis in a zebrafish model. a Representative images of xenografted zebrafish larvae, treated with or without 2.5mM MTZ at 24hpi. b Quantification of the angiogenic capacity of cancer cells with and without macrophages. c Xenografted zebrafish material was retrieved and used to detect angiogenetic and inflammatory factors with qPCR. d Expression levels of zebrafish VEGF-A (vegfaa), TGF-β (tgfb1a), and IL-10 (il10) in CRMM1 and CRMM2 engrafted groups. e Expression of the M2 marker IL-4 (il4) in tumor engrafted zebrafish treated with DMSO and MTZ. f Expression of proinflammatory markers, iNOS (nos2a), IL-1β (il1b), and TNF-α (tnfa) in DMSO or MTZ-treated groups

Expression Data

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Antibody Labeling

Phenotype Data

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