FIGURE

Fig. 6

ID

ZDB-FIG-240916-70

Publication

Aky�rek et al., 2024 - The Accordion Zebrafish tq206 Mutant in the Assessment of a Novel Pharmaceutical Approach to Brody Myopathy

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Cellular expression and localization of WT and mutant SERCA1 protein in HeLa cells. Cells were transfected with WT or with S766F mutated SERCA1 cDNAs, as indicated. Sixteen hours after transfection, MG132 (10 ?M final concentration dissolved in DMSO), DMSO (its vehicle 0,1%) and different concentrations of C17 (5 ?M, 10 ?M, 20 ?M) or C4 (10 ?M, 15 ?M, 20 ?M) CFTR correctors, were added and cells were incubated for 8h. Transfected and treated cells were immunolabelled with monoclonal antibodies to SERCA1 and then incubated with the Alexa 568 red fluorescence secondary antibody. Images were recorded at the same setting conditions and magnification (scale bar 50 �m).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.