FIGURE

Fig. 4

ID

ZDB-FIG-240916-68

Publication

Aky�rek et al., 2024 - The Accordion Zebrafish tq206 Mutant in the Assessment of a Novel Pharmaceutical Approach to Brody Myopathy

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Fig. 4

Muscle fiber integrity, the skeletal muscle histology and SERCA1 mRNA expression levels assessments. (A,B) Representative images (A) and quantification of birefringence (B) of wild-type (WT), Tq206+/?, and Tq206?/? embryos are presented. Scale bar: 1 mm. Quantitative data are presented as mean � SEM (Kruskal-Wallis test followed by Dunn?s post hoc test, ns, non-significant; *, p ? 0.05; *** p ? 0.001). (C) Hematoxylin & Eosin (panels (a,b), scale bar 500 �m), Azan-Mallory staining (panels (c,d), scale bar 50 �m), and SERCA1 immunostaining (panels (e,f), scale bar 20 �m) in muscle sagittal sections of WT (a,c,e,g) and Tq206+/? (b,d,f) zebrafish. In panel d, arrows indicate fibrotic tissue (colored in blue) presence. Negative control of the immunohistochemistry is shown in (g). (D) SERCA1 mRNA expression levels in WT, Tq206+/? and Tq206?/?, were quantified by Real Time RT-PCR. Data are presented as mean � SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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