FIGURE

Figure 2—figure supplement 1.

ID

ZDB-FIG-240617-45

Publication

Noonan et al., 2024 - A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma

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Figure 2—figure supplement 1.

TGFb responsive melanoma cells down-regulate interferon target genes.

(A) UMAP with no batch correction of 2 MCR:MCS replicate melanomas combined in Figure 2A. Approximately 2,256 TIE:EGFP⁺ cells and 752 mitfa:mCherry⁺; TIE:EGFP^- cells (as a control) were sorted for scRNA-seq. (B) (Top) Dotplot depicting interferon target gene expression in TIE:EGFP^high, TIE:EGFP^low, and TIE:EGFP^- melanoma cells. (Bottom) GSEA enrichment plot reveal down-regulated interferon gamma (q=0.01) in TIE:EGFP⁺ melanoma cells. The internal control for these comparisons was TIE:EGFP^- melanoma cells from the same tumor.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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