FIGURE

Fig 2

ID

ZDB-FIG-240614-63

Publication

Belt et al., 2024 - Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos

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Fig 2

Accumulation of MLL positive cells on the yolk results from migration defects and not cardiovascular or hematopoietic defects.

Average heart rates of control and lyz:MLL-ENL injected embryos at 48 hpf (A, N = 10). MLL (yolk) and lyz expression in control (B,C) and MLL-ENL expressing embryos (D,E). The number of lyz positive cells in the CHT in control and lyz:MLL-ENL injected embryos at 72 hpf (F, N = 12–18). MLL/Tal1 (G-I, arrows–tal1, red arrowheads-MLL, 24 hpf) and MLL/runx1/cmyb (J-L, black arrowheads-runx1/cmyb, red arrowheads-MLL, 36 hpf) expression were analyzed in control (G,J, N = 15–30), lyz:MLL-ENL (H,K, N = 13–30), and lyz:MLL-AF9 (I,L, N = 17–25) embryos. Still images at 0, 5 and 10 minutes from spi1b:GFP timelapse videos for control (M) and lyz:MLL-AF9 (N) embryos. Statistical analysis was conducted using student’s t-test. * p<0.05. Anterior to the left.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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